According to the study published in the journal JAMA Pediatrics, the incidence of myopericarditis is higher in males after the second dose of the vaccine. The study suggested that low incidence rates and favorable outcomes of COVID vaccine-associated myopericarditis have been largely observed in adolescents and young adults.

The meta-analysis study comprising 23 studies and including 854 patients aged 12 to 20 years revealed that the risk of myocarditis, pericarditis, or myopericarditis was two- to threefold higher after a second dose of the Moderna Spikevax Covid-19 vaccine in comparison to the Pfizer BioNTech Covid-19 vaccine. The author of the study noted that the risk of developing myocarditis after SARS-CoV-2 infection is significantly higher than after COVID-19 mRNA vaccination.

However, the study concluded that the overall cases of heart inflammation associated with either vaccine were very rare. Additionally, the benefits of the mRNA COVID-19-19 vaccination are deemed to outweigh the potential risks. 

(Source: https://www.tribuneindia.com/news/health/vaccine-linked-heart-inflammation-high-in-males-after-2nd-dose-study-458319 )